Stage-gate process for life sciences and medical innovation investment

Life science innovation has led to significant improvements in clinical outcomes and has been a source of financial growth for individuals and institutions capable of performing appropriate investments in this sector. Several groups have developed methodologies to assist medical technology innovators in the design and development activities. Unfortunately, these tools have not aided the general investment community to profit from these enterprises. This situation has contributed to a general reduction in risk capital directed towards life sciences compared to other industries. We review the current investment practices in the life science sector and present a comprehensive stage-gate model that aims to captures this investment process. An analysis of best practices and in-depth interviews with 68 life sciences investors and entrepreneurs worldwide are used to support such model. A single case-control study comparing life science investment execution within two similar investment firms was conducted to evaluate feasibility in the implementation of these practices. The stage-gate model includes (I) General vision and investment strategy definition; (II) Venture search, screening and rapid pre-evaluation; (III) Due diligence and negotiation of terms; (IV) Portfolio management, evaluation, and exit. The difference in execution of investment and results from a post-performance Root Cause Analysis were consistent with a reduction in perceived risk from the case company trained with the proposed model compared to the control. This suggests that our developed model and process may be useful in encouraging life sciences investment via evidence-based evaluations.     

材料试验检测技术在公路工程中的应用分析

试验检测技术作为当前对公路路面施工中工程质量保证当中的重要环节,对路面工程施工的质量有着重要的作用。本文以公路路面养护中的主要材料试验检测方法和指标作为基础,从材料试验检测的作用和实际应用对其进行阐述,并指出在养护中运用这些指标和方法的重要性。     

刍议贵州体育高考男子800米项目体能分配

本文就贵州体育高考男子800米项目体能分配进行了分析和研究,并提出了合理化建议。     

计算机技术在建筑材料检测中的应用研究

计算机的智能化、科学化与高效化特点,使其在现代建筑材料检测中得到了广泛的应用。本文对计算机技术的应用意义进行了介绍,同时探讨了计算机技术在建筑材料检测各个环节的应用,最后对计算机技术应用于建筑材料检测时的系统组成进行了分析。     

设备类实践教学教材系统性知识体系探讨

我国工科院校认识实习和生产实习的实践教学大都各自编写讲义,其内容都比较零散,没有形成系统性的知识体系。这与社会企业需求的重点知识内容和难点知识内容有较大的差距,导致了实践教学质量不能大幅提高。依据社会企业需求的基本点、重点和难点知识内容,构成认识实习和生产实习全过程的三个层次的系统性知识体系,必将大幅度提高专业教师实践教学水平、实践教学教材建设和实践教学质量。     

高校公共关系学专业课程体系改革问题研究

公共关系学专业在我国经历了十九年的专业建设,现今已经取得了显著成绩.但专业的课程体系问题一直存在,为了解决这一现实问题,本文从内蒙古高校公共关系学专业课程体系设置的现状人手,分析其存在的不足,提出相应的对策.旨在培养大批符合时代要求的公共关系专业人才.     

强化周转材料管理 提升项目经济效益

在工程项目施工过程中,为了提高经济效益,需要对材料加强管理,本文通过周转材料配置、使用、考核、回收等环节进行阐述,同时提出相应的管理建议,为企业施工提供参考依据。     

科技翻译人才培养的探讨

在科技迅猛发展的二十一世纪,社会对高水平科技英语翻译人才的需求缺口依然很大。本文对《科技英语翻译实用教程》进行了简要评析,指出重视科技英语翻译教材的建设,重视翻译教学,将有利于解决高校科技翻译人才培养与社会市场实际需求脱节的现实矛盾。     

The theory and practice of performance measurement

This paper builds on principles and techniques developed in measurement science, as currently understood in physical sciences and engineering, to improve the theory and practice of performance measurement. To do so, it firstly discusses three fundamental positions on measurement, characterized as metaphysical, anti-metaphysical and relativistic. Subsequently, it lays the foundations of a pragmatic epistemology of measurement in both physical and social sciences. Finally, these insights are integrated through the examination of possible advances in both the theory and practice of performance measurement in organizations.     

基于多级库存的电网运维物资安全库存优化配置研究

针对电力公司运维物资多级库存体系与安全库存配置现状,结合安全库存聚集效应,文章提出了周转库安全库存差异聚集策略。在综合考虑库存持有成本与普通、紧急配送成本的基础上,构建了安全库存优化配置模型。通过两类电网运维物资实际数据的分析,验证了差异聚集策略下成本低于全部聚集以及全部分散策略,可以为电力公司物资集约化、差异化、精益化管理以及仓库定额配置提供依据。